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Low Dose Naltrexone Compounding
Prescription pills out of the bottle.

Low Dose Naltrexone Compounding

Naltrexone is a medication originally approved for opioid addiction and alcoholism treatment. It is a mu-opioid antagonist that is a combination of two distinct shapes known as isomers. The research suggests that the L isomer binds to opioid receptors while the D isomer binds to immune cells.

As an opioid antagonist, naltrexone binds to and blocks opioid receptors on cells in the body. Using naltrexone in low doses causes the receptors to be blocked intermittently, and the receptor sites rebound with increased production of endorphins. Endorphins are “natural, endogenous opioids” best known for relieving pain, enhancing a sense of well-being, and regulating the immune system.

Increased endorphin release:
  • May lessen pain

  • Downregulates inflammatory cytokines, while increasing white blood cells

  • Stimulates mucosal and tissue healing

  • May inhibit tumor growth

  • Reduces the death of the cells that produce myelin in the brain, thereby protecting the covering of nerves

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LDN has also been shown to block some non-opioid receptors (toll-like receptors, TLR4), which reduce inflammatory cytokines and suppress the body’s immune response and inflammation. LDN has demonstrated the ability to reduce the severity of symptoms in certain inflammatory conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome (CRPS).

Before starting LDN, a full review of medications and supplements should be completed. Modifications of doses for other maintenance medications may need to coincide with the start of LDN. LDN is well tolerated in most patients, and side effects tend to be transient. However, care should be taken to slowly titrate the dose to avoid side effects.

Some common side effects may include:
  • Sleep disturbances/vivid dreams

  • Gastrointestinal upset, nausea

  • Mild headache

  • Mild agitation

Compounding pharmacists have specialized training and will work with medical professionals to guide dosing protocols for various conditions. The most common “rule of thumb” is to start with a lower dose and increase slowly.

Low Dose Naltrexone does require a prescription written by a physician. We will gladly work with you and your doctor to titrate and achieve the right dose for you.

Please contact our compounding pharmacy to discuss your specific needs or questions.

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